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Peternus

09 Apr 2025 - 09:39 pm

Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
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Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.

Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.

The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
“This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.

First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.

Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.

“We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”

Harming infant health
The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.

Within a day or two of birth, the authors collected the babies’ blood via a heel stick.

The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.

Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.

Robertvon

09 Apr 2025 - 08:17 pm

‘A whole different mindset’
Accurate clockwork is one matter. But how future astronauts living and working on the lunar surface will experience time is a different question entirely.
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On Earth, our sense of one day is governed by the fact that the planet completes one rotation every 24 hours, giving most locations a consistent cycle of daylight and darkened nights. On the moon, however, the equator receives roughly 14 days of sunlight followed by 14 days of darkness.

“It’s just a very, very different concept” on the moon, Betts said. “And (NASA is) talking about landing astronauts in the very interesting south polar region (of the moon), where you have permanently lit and permanently shadowed areas. So, that’s a whole other set of confusion.”
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“It’ll be challenging” for those astronauts, Betts added. “It’s so different than Earth, and it’s just a whole different mindset.”

That will be true no matter what time is displayed on the astronauts’ watches.

Still, precision timekeeping matters — not just for the sake of scientifically understanding the passage of time on the moon but also for setting up all the infrastructure necessary to carry out missions.

The beauty of creating a time scale from scratch, Gramling said, is that scientists can take everything they have learned about timekeeping on Earth and apply it to a new system on the moon.

And if scientists can get it right on the moon, she added, they can get it right later down the road if NASA fulfills its goal of sending astronauts deeper into the solar system.

“We are very much looking at executing this on the moon, learning what we can learn,” Gramling said, “so that we are prepared to do the same thing on Mars or other future bodies.”

Alonzomails

09 Apr 2025 - 08:10 pm

Space, time: The continual question
If time moves differently on the peaks of mountains than the shores of the ocean, you can imagine that things get even more bizarre the farther away from Earth you travel.
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To add more complication: Time also passes slower the faster a person or spacecraft is moving, according to Einstein’s theory of special relativity.

Astronauts on the International Space Station, for example, are lucky, said Dr. Bijunath Patla, a theoretical physicist with the US National Institute of Standards and Technology, in a phone interview. Though the space station orbits about 200 miles (322 kilometers) above Earth’s surface, it also travels at high speeds — looping the planet 16 times per day — so the effects of relativity somewhat cancel each other out, Patla said. For that reason, astronauts on the orbiting laboratory can easily use Earth time to stay on schedule.
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For other missions — it’s not so simple.

Fortunately, scientists already have decades of experience contending with the complexities.

Spacecraft, for example, are equipped with their own clocks called oscillators, Gramling said.

“They maintain their own time,” Gramling said. “And most of our operations for spacecraft — even spacecraft that are all the way out at Pluto, or the Kuiper Belt, like New Horizons — (rely on) ground stations that are back on Earth. So everything they’re doing has to correlate with UTC.”
But those spacecraft also rely on their own kept time, Gramling said. Vehicles exploring deep into the solar system, for example, have to know — based on their own time scale — when they are approaching a planet in case the spacecraft needs to use that planetary body for navigational purposes, she added.

For 50 years, scientists have also been able to observe atomic clocks that are tucked aboard GPS satellites, which orbit Earth about 12,550 miles (20,200 kilometers) away — or about one-nineteenth the distance between our planet and the moon.

Studying those clocks has given scientists a great starting point to begin extrapolating further as they set out to establish a new time scale for the moon, Patla said.

“We can easily compare (GPS) clocks to clocks on the ground,” Patla said, adding that scientists have found a way to gently slow GPS clocks down, making them tick more in-line with Earth-bound clocks. “Obviously, it’s not as easy as it sounds, but it’s easier than making a mess.”

Darnellvot

09 Apr 2025 - 07:16 pm

Space, time: The continual question
If time moves differently on the peaks of mountains than the shores of the ocean, you can imagine that things get even more bizarre the farther away from Earth you travel.
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To add more complication: Time also passes slower the faster a person or spacecraft is moving, according to Einstein’s theory of special relativity.

Astronauts on the International Space Station, for example, are lucky, said Dr. Bijunath Patla, a theoretical physicist with the US National Institute of Standards and Technology, in a phone interview. Though the space station orbits about 200 miles (322 kilometers) above Earth’s surface, it also travels at high speeds — looping the planet 16 times per day — so the effects of relativity somewhat cancel each other out, Patla said. For that reason, astronauts on the orbiting laboratory can easily use Earth time to stay on schedule.
https://kra30c.cc
кракен даркнет
For other missions — it’s not so simple.

Fortunately, scientists already have decades of experience contending with the complexities.

Spacecraft, for example, are equipped with their own clocks called oscillators, Gramling said.

“They maintain their own time,” Gramling said. “And most of our operations for spacecraft — even spacecraft that are all the way out at Pluto, or the Kuiper Belt, like New Horizons — (rely on) ground stations that are back on Earth. So everything they’re doing has to correlate with UTC.”
But those spacecraft also rely on their own kept time, Gramling said. Vehicles exploring deep into the solar system, for example, have to know — based on their own time scale — when they are approaching a planet in case the spacecraft needs to use that planetary body for navigational purposes, she added.

For 50 years, scientists have also been able to observe atomic clocks that are tucked aboard GPS satellites, which orbit Earth about 12,550 miles (20,200 kilometers) away — or about one-nineteenth the distance between our planet and the moon.

Studying those clocks has given scientists a great starting point to begin extrapolating further as they set out to establish a new time scale for the moon, Patla said.

“We can easily compare (GPS) clocks to clocks on the ground,” Patla said, adding that scientists have found a way to gently slow GPS clocks down, making them tick more in-line with Earth-bound clocks. “Obviously, it’s not as easy as it sounds, but it’s easier than making a mess.”

Alonzoinfal

09 Apr 2025 - 07:15 pm

Lunar clockwork
What scientists know for certain is that they need to get precision timekeeping instruments to the moon.
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Exactly who pays for lunar clocks, which type of clocks will go, and where they’ll be positioned are all questions that remain up in the air, Gramling said.

“We have to work all of this out,” she said. “I don’t think we know yet. I think it will be an amalgamation of several different things.”
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Atomic clocks, Gramling noted, are great for long-term stability, and crystal oscillators have an advantage for short-term stability.
“You never trust one clock,” Gramling added. “And you never trust two clocks.”

Clocks of various types could be placed inside satellites that orbit the moon or perhaps at the precise locations on the lunar surface that astronauts will one day visit.

As for price, an atomic clock worthy of space travel could cost around a few million dollars, according Gramling, with crystal oscillators coming in substantially cheaper.

But, Patla said, you get what you pay for.

“The very cheap oscillators may be off by milliseconds or even 10s of milliseconds,” he added. “And that is important because for navigation purposes — we need to have the clocks synchronized to 10s of nanoseconds.”

A network of clocks on the moon could work in concert to inform the new lunar time scale, just as atomic clocks do for UTC on Earth.

(There will not, Gramling added, be different time zones on the moon. “There have been conversations about creating different zones, with the answer: ‘No,’” she said. “But that could change in the future.”)

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